JUL 07, 2020 9:00 AM PDT

Enhancing risk stratification in early colon cancer with TNM-I (Immune) staging: focus on stage II T4N0 patients

Sponsored by: HalioDx
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Director, Inserm, Cordeliers Research Center, Paris, France
    Biography
      Jérôme Galon is director of research at INSERM (French NIH) and head of the laboratory of Integrative Cancer Immunology, in Paris, France. He is also associate director and co-founder of the European Academy of Tumor Immunology (EATI), board member of the Society for Immunotherapy of Cancer (SITC), co-founder of HalioDx company and the chairman of its scientific council. His work on the comprehensive analysis of the tumor microenvironment led to the concept of cancer immune contexture.

      Jérôme Galon pioneered Immunoscore and is the principal investigator of the Worldwide Immunoscore Consortium. He has been consultant and/or served on the scientific advisory board of 28 biotech and pharmaceutical companies. His contributions have been recognized with numerous awards, including the William B Coley Award, USA (2010), the prestigious European Patent Office (EPO, EU) as European Inventor 2019 for his Immunoscore®, the Senior Research Prize Jean Valade from the Fondation de France (2020) and on January 1st 2020, he was appointed Knight of the Legion of Honour by presidential decree.
    • Medical Science Director, HalioDx Inc.
      Biography
        Dr. Poage joined HalioDx in 2019, to coincide with the launch of the Immunoscore assay for early stage colon cancer in the US and to build the Medical Affairs/Market Access functions. Prior to HalioDx, he was a medical scientist at Biotheranostics, where he conducted collaborative clinical research studies and brought awareness to unmet needs in medical oncology. His past work focused on basic biology and biomarker-driven research in women's cancers while a Laboratory Director in the Department of Clinical Investigations at the Brooke Army Medical Center in San Antonio. During his time in fellowship at the University of Texas - MD Anderson Cancer Center in Houston, Texas he also focused on biomarker research in women's cancers. Dr. Poage holds a B.A. in Biochemistry from Colby College and a Ph.D. in Molecular Pharmacology, Physiology, and Biotechnology from Brown University.

      Abstract

      DATE:  July 07, 2020

      TIME:   9:00 am PDT

       

      The widely used TNM staging system is poorly predictive of response to adjuvant chemotherapy in Stage II and III colon cancer. As a result, there is overutilization of adjuvant chemotherapy in some patients at low risk for recurrence, and underutilization in patients at high risk for recurrence. There is a strong unmet need for a better prognostic and predictive tool to personalize treatment decisions in colorectal cancer.

      The World Health Organization (WHO) recently introduced immune response as an essential and desirable diagnostic criterion for CRC alongside standard histological parameters, indicating that assessment of immune response is now an essential complement to standard staging procedures. Immunoscore® is the first consensus, standardized and commercially available test clinically validated for this assessment.

      This webinar will focus on our latest data presented at ASCO 2020 and ESMO-GI 2020. First, prognostic performance on T4N0 colon cancer patients will be presented, showing that Immunoscore® identifies which patients have a lower risk of recurrence who might be spared adjuvant chemotherapy. Secondly, use of TNM-Immune (TNM-I) classification system to determine treatment benefit in selected patients will be discussed.

       

      Learning Objectives:

      • Understand the value of Immunoscore® on top of standard tools for early stage Colon Cancer patients
      • Evaluate impact of Immunoscore® on treatment decisions for T4N0 Colon Cancer patients
      • Outline the utility of a TNM-I approach for Colon Cancer risk assessment

       

      Webinars will be available for unlimited on-demand viewing after live event.

       

      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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