OCT 15, 2020 9:00 AM PDT

Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug Interactions Applications

Sponsored by: Emulate Bio
Speakers
  • Senior Vice President, Laboratory Corporation of America Holdings Chief Scientific Officer, Covance
    Biography
      Steven Anderson is senior vice president and chief scientific officer for Covance Drug Development. He has worked for LabCorp for 30 years and has held a variety of positions, including director of operations for ViroMed Laboratories, director of operations for Monogram Biosciences, director of operations for the Center for Molecular Biology and Pathology, director of operations for Integrated Oncology and Integrated Genetics, national director of research and development, and global head of LabCorp Clinical Trials. His research interests include Molecular Pathology and Oncology based biomarkers, and that work has resulted in the development and validation of multiple companion diagnostics and pharmacogenomic assays in clinical use today.


       


      He holds a doctorate in genetics from Iowa State University and was an American Cancer Society postdoctoral fellow at the Waksman Institute of Microbiology at Rutgers University.
    • Vice President of Technology Implementation & Field Science at Emulate
      Biography
        Kyung-Jin (KJ) Jang, Ph.D., is Vice President of Technology Implementation & Field Science at Emulate. She has built a pioneering position within the Organs-on-Chips field through her multidisciplinary experiences since she first started the Kidney-on-a-Chip research in 2007. Dr. Jang’s work has focused on the development and commercialization of multiple Organs-on-Chips models and their applications to disease modeling and drug discovery.


         


        Prior to joining Emulate as one of the founding scientists and a Principal Investigator and R&D Lead, Dr. Jang and the Organs-on-Chips project team developed multiple Organ-Chip models, including liver, lung, kidney, intestine, brain, and skin for 5 years at the Wyss Institute for Biologically Inspired Engineering at Harvard University.


         


        She received her Ph.D. from the Interdisciplinary Program in Nano-Science and Technology at Seoul National University in South Korea, has earned recognition for academic excellence, and has received many honors in the field of bioengineering and toxicology. She has authored or co-authored 21 research publications and 2 book chapters.
      • Executive Director at Covance Laboratories
        Biography
          Don has been with Covance since August 2009 and is Covance’s global business lead for Drug Metabolism and Lead Optimization. In this role he is the business unit and scientific leader working to develop partnerships with clients to enable the further advancement of compounds through the various discovery and development stage gates. Don received his B.S. in Biochemistry from Michigan State University and his Ph.D. in Medicinal Chemistry from the University of Michigan under the guidance of Kevin Rice.


           


          Following his degree work, Don joined Pfizer Global Research & Development, Ann Arbor Laboratories in 2000 as a Scientist in the department of Pharmacokinetics, Dynamics & Metabolism (PDM). His initial role was part of the structural elucidation team and he advanced through the organization to eventually lead the Mechanistic Metabolism group. Additionally, Don was part of a number of development teams including the Schizophrenia/Biopolar Research Clinical Management Team, a global multidisciplinary team accountable for developing and executing the strategy for the Pfizer schizophrenia/biopolar late discovery and early development portfolio.


           


          In 2007, Don moved to Schering-Plough to manage the Discovery Metabolite Identification group in Kenilworth, NJ. In leading this group, he focused on applying metabolite identification to understand the role of biotransformation and its relationship to broader metabolic issues in order to better fit structural elucidation results into the larger DMPK package.

        Abstract
        Date:  October 15, 2020
        Time: 9:00am (PDT),  12:00pm (EDT)
         
        Renal transporters play an important role in potential clinical drug-drug interactions (DDIs) as highlighted in the FDA, EMA and PMDA regulatory guidance documents. Conventionally available experimental models yield data on limited numbers of transporters in a given system. This is generally not predictive of clinical outcomes due to in vitro-in vivo discrepancies because of the interplay of multiple transporters in the proximal tubule. Since DDIs are important to clinical outcomes, with the ever increasing amount of polypharmacy there is an unmet need for a human-relevant model to study renal drug transport.
         
        Covance and Emulate are collaborating to evaluate the Proximal Tubule Kidney-Chip to study transporter-mediated DDIs to fill the gap between current in vitro options and clinical trials.
         
        In this webinar, scientists from Emulate and Covance will showcase promising new data on characterization of the Kidney-Chip as a model to study and predict potential drug-drug interactions. There will be three webinar speakers:
         
        • Steve Anderson PhD, CSO of Covance, will outline the need for more human-relevant cell-based to improve translation of preclinical data to the clinic and get safer, more efficacious
         
        • Kyung-Jin (KJ) Jang, Ph.D, VP of Technology Implementation & Field Science at Emulate, will highlight the Human Emulation System, an Organs-on-Chips platform that recreates the required microenvironment to enable physiologically relevant function in a human cell-based system, as a new solution to study and predict transporter-mediated DDIs
         
        • Donald McKenzie PhD, Covance’s global business lead for Drug Metabolism and Lead Optimization, will present proof-of-concept data to characterize the Proximal Tubule Kidney-Chip including efflux activities using probe substrates such as digoxin mediated by P-gp; tetraethylammonium and metformin mediated collaboratively by OCT1/2, MATE1, and MATE2-K; and para aminohippuric acid mediated by OAT1/3. The data to be presented also includes functional modulation of efflux by known inhibitors of specific transporters.
         
         
        Webinars will be available for unlimited on-demand viewing after live event.
         
        LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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