Professor Stockwell will discuss the discovery of ferroptosis, a novel model of regulated but non-apoptotic cell death. He will describe how some tumors are sensitized to ferroptosis and may be targeted with compounds that inhibit cystine-glutamate exchange or the lipid repair enzyme Gpx4, leading to ferroptotic cell death. In addition, he will discuss small molecule inhibitors of ferroptosis, and how such compounds have been used to implicate activation of ferroptosis in numerous degenerative diseases.