Exploring Spatial Biology: 2D, 3D, and 4D Atlasing of the Human Body

Join us for a live webinar on the latest advancements in spatial biology. Featuring two insightful presentations, learn how cutting-edge imaging and single-cell technologies are transforming our understanding of human organs in health and disease. This event includes live discussions and a Q&A session, allowing you to engage directly with experts and gain insights into advanced imaging technologies in biomedical research.

 

Explore the power of multiplexed 3D imaging to study organ microenvironments. See how large-scale, label-free imaging reveals critical spatial relationships between cell types and their roles in organ function, injury, and fibrosis. [SEE FULL ABSTRACT]

 

Learn how high-resolution single-cell genomics and spatial technologies map cellular diversity across time and space. Understand how detailed spatial atlases of developing tissues and organs provide insights into human biology and disease mechanisms. [SEE FULL ABSTRACT]

 

 

Don't miss this opportunity to stay at the forefront of spatial biology and its impact on biomedical research. Register now to secure your spot!

 

 

 

 

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Understanding the complex organization of organs in health and disease is challenging, particularly when various cell types can transition between various states. This is especially true for the kidney, where the 3-dimensional (3D) spatial organization of cell populations into functional tissue units is critical for performing major physiological functions that maintain systemic homeostasis. Recent advances in large- scale, label-free, and multiplexed fluorescence 3D imaging have unlocked novel insights into the organization of kidney micro-environments in health and disease. These developments have opened new possibilities for understanding key spatial relationships governing the interactions between epithelial, endothelial, immune, and stromal cells. Many of these processes could also have implications for the development of organ injury and fibrosis, which are hallmarks of organ dysfunction and chronic disease. Dr. Tarek Ashkar will discuss ongoing efforts by major consortia to create a spatial atlas of the kidney. Additionally, Dr. Ashkar will explore how large-scale 3D imaging offers advantages in accurate cell phenotyping and niche analysis at the cell and functional tissue unit levels, and how such methodologies will be key to defining processes such as the link between vascular dysfunction and fibrosis.

 

 

The 37 trillion cells of the human body exhibit a remarkable array of specialized functions and must cooperate and collaborate in time and space to construct a functioning human. By harnessing cutting-edge single-cell genomics and spatial technologies, the Teichmann laboratory has been working to understand this cellular diversity, how it is generated during development, and how it goes awry in disease. Dr. Sarah Teichmann will illustrate how cell atlasing in three spatial dimensions and across developmental time can accelerate our understanding of how functioning tissues and organs are formed in the body.