SEP 15, 2020 8:00 AM PDT

Next generation ultra high content analysis of the tumor immune microenvironment using MICS technology

Sponsored by: Miltenyi Biotec
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Global Customer Liaison Manager
    Biography

      Dr. Stefan Eulitz is the Global Customer Liaison Manager at Miltenyi Biotec. With almost 10 years’ cyclic immunofluorescence experience in industry and academia, Stefan combines bench and business knowledge. During his PhD at Rheinische-Friedrich-Wilhelms-Universität Bonn, and as a consultant at French company Alcimed, he gained deep knowledge of drug target and biomarker discovery. Stefan joined Miltenyi Biotec in 2015 to support the development of the MACSima Imaging Platform as Deputy Development Program Leader, and currently supports researchers in the adaption of this technology from basic R&D to commercial research strategies.


    Abstract

    DATE: September 15, 2020

    TIME:  08:00am PT

     

    Tumorigenesis and cancer progression are affected by the tumor immune microenvironment (TIME). The TIME not only influences the efficiency of existing therapies but is also very much a focus area in the development of new therapeutics. Flow cytometry–based experiments to characterize the TIME allow analysis of up to 40 markers per run; however, they lack any information on spatial distribution and cellular interactions. Conversely, classical fluorescence microscopy–based approaches provide spatial information but only allow the analysis of a maximum of 10 markers per sample. Even novel image-based multiplexing technologies are not able to provide insights that go much deeper than high-end flow cytometric options with respect to the number of markers. MICS technology is based on innovative use of next-generation cyclic immunofluorescence staining, and overcomes these drawbacks by using an iterative staining and erasing process, which allows for the analysis of 100+ markers on a single sample, whilst retaining that critical information on special distribution and cellular interactions. Stefan Eulitz, Global Customer Liaison Manager and former Deputy Development Program Leader of the MACSima™ Imaging Platform at Miltenyi Biotec, will show how MICS technology has ushered in a new era in high content imaging – ultra high content imaging, whilst providing insights into the analysis of the TIME in different tumor samples in an unrivaled depth.

     

    Learning Objectives:

    • Define the optimal number of markers for characterization of the TIME
    • Review MICS technology for next generation cyclic immunofluorescence staining
    • Analyze the tumor immune microenvironment using ultra high content imaging

     

    Webinars will be available for unlimited on-demand viewing after live event.

     

    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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