Genetic Approaches and Host Targets to Inhibit Influenza Virus Pathogenesis

Influenza viruses represent a significant burden to human health.  In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed.  We have performed a number of genetic screens to identify host factors that can either directly restrict infection or modulate the immune response to better control the virus.  Those data and thoughts on the future development of host-directed antiviral therapeutics will be discussed in this presentation.

Learning Objectives:
1. Understand how host proteins can be targeted to prevent viral disease.
2. Explain theoretical advantages and disadvantages for host-directed therapeutics.