MAR 28, 2024 8:00 AM PDT

Identification of Frequent Autoreactive B-cell Response in Pancreatic Ductal Adenocarcinoma Using Cell Sorting and Single-Cell Sequencing

Sponsored by: Sony Biotechnology

Event Date & Time
Date: March 28, 2024
Time: 8:00 AM (PDT), 11:00 AM (EDT), 15:00 (GMT), 16:00 (CET)
B cell responses within pancreatic ductal adenocarcinoma (PDAC) tumors are associated with improved patient outcomes, yet the specific triggering antigens remain largely unknown. In this webinar, Dr. Min Yao will present a methodology that combines cell sorting, single-cell RNA sequencing (scRNA-Seq), and immunoglobulin (Ig) sequencing of tumor-infiltrating immune cells to uncover these antigens. Dr. Yao's study shows evidence of various immune responses, including activated T and B cells, germinal center reactions, and plasma cells producing antibodies targeting intracellular self-antigens in pancreatic cancer tissue. These findings indicate a potential link between chronic inflammation in pancreatic cancer and an enhanced adaptive immune response, which could have implications for treatment development.
Learning Objectives
  • Understand the immune micro-enviorment in pancreatic ductal adenocarcinoma (PDAC) using the SH800 Cell sorter and 10x Genomics single-cell analysis tools
  • Learn how to identify specific antigens associated with B cell responses in clinical samples
  • Gain insights on autoreactive B cell responses in PDAC and its potential clinical impact
Webinars will be available for unlimited on-demand viewing after live event.

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