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Nov 12, 2020

The Importance of Tissue Chemistry in Immunity-Oncology

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Professor Emeritus of Pathology, University of Arizona; Founder and Chief Scientific Advisor Emeritus, Ventana Medical Systems, Inc., a division of Roche
    Biography
      Dr. Thomas Grogan, MD, is professor emeritus at the University of Arizona College of Medicine. He is the founder and chief scientific advisor emeritus at Ventana Medical Systems, Inc., a division of Roche, a leading international healthcare leader based in Basel, Switzerland. Dr. Grogan grew up in unusual circumstances, as the son of a CIA officer father and a steel-willed mother, whose three sons experienced childhoods filled with peril in several foreign countries. He graduated from the University of Virginia, Phi Beta Kappa, with a degree in biology, and earned his medical degree with honors from the George Washington University School of Medicine. During his time in medical school, Dr. Grogan studied tropical medicine in Cebu, the Philippines. He did his internship and residency in the U.S. Army at Letterman Hospital in San Francisco and at Walter Reed Army Medical Center in Washington, D.C. He was a post-graduate fellow in hematopathology at Stanford University. A founding member of the International Lymphoma Study Group, Dr. Grogan has authored more than two hundred and fifty scientific papers and holds eighteen patents. His clinical practice contributions have been recognized in the Best Doctors in America, published by Woodward/White, Inc.) continuously from 1991 until his retirement in 2017. Chief among his innovations is the automation of cancer pathology testing technology that enables physicians to accurately identify the genetic characteristics of their patients' disease and manage their personalized treatment. Dr. Grogan has also been recognized for his medical and business accomplishments with many prestigious awards, including American Cancer Society Gift of Life Award (2003), Ernst and Young Entrepreneur of the Year Award (2002), Tom Brown Excellence in Entrepreneurship Award (2002), University of Arizona Outstanding Technology Innovation Award (2004). Dr. Grogan is a husband, father and grandfather, and he lives in Tucson, Arizona, with his wife of fifty-two years, Cande, who was a successful restaurateur.

    Abstract

    Cancer cells can acquire immune resistance resulting in a loss of immunosurveillance. Tumor cells can upregulate PDL-1 which binds to PD-1. This complex inhibits CD8 Tumor Infiltrating cells ( TILs) response to tumor antigens inducing immune blockade. Anti-blockade immunotherapy blocks the blockade and restores immunosurveillance (self-healing).This presentation emphasizes clinical examples of immunotherapy with both an individual patient with malignant melanoma and population-based examples including triple negative breast cancer.. The cases demonstrate the importance of intact tissue chemistry, in particular multi-analyte immunohistochemistry to inform treatment.. It emphasizes the future need to add more markers and cancer types to the testing repertoire and the need to go beyond diagnosis to prediction and monitoring of immunotherapy responses.

    Learning Objectives:

    1. Understand the concepts of tumor immunosurveillance, immune blockade, and immune restoration via immunotherapy

    2. Understand the pivotal role of the diagnostic laboratory in informing immunotherapy by using intact multi-analyte immunohistochemistry.


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