Director of Applications Development, Nicoya
BIOGRAPHY
MAR 28, 2024 10:00 AM PDT
Introduction to Digital SPR and its use in assessing the binding kinetics of DART (Drugs Acutely Restricted by Tethering).
Speakers
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Victoria Goldenshtein, Ph.D.
Postdoctoral Associate, Duke UniversityBIOGRAPHY
Event Date & Time
Date: March 28, 2024
Time: 10am PDT, 12pm CDT, 1pm EDT
Abstract
Digital SPRTM is a next-generation technology for characterizing biomolecular interactions. By combining digital microfluidics (DMF) with SPR, digital SPR systems can effectively bypass common challenges found in traditional SPR and BLI platforms.
Understanding drug mechanisms in complex systems, particularly in the brain, remains challenging despite advancements at the molecular level. Yet, cell-specific technologies like DART provide a promising solution, enabling targeted drug delivery to genetically defined neuronal cell types, thereby allowing the observation of the drug effects on brain dynamics and animal behavior. (Shields et al., bioRxiv, 2022, Shields et al., Science, 2017).
The underlying principle of DART technology is the covalent interaction between a protein and its target chemical molecule. In this webinar, we will discuss the optimization of the covalent capture affinity of DART, and the subsequent functional analysis of binding kinetics, using digital SPR.
- What digital SPR is and how it works.
- See how data quality and throughput are maximized using the latest advances in digital SPR to eliminate artifacts, optimize accuracy, and automate tedious, error-prone sample preps.
- See how researchers at Duke University utilize this technology to rapidly assess the binding kinetics of a covalent interaction between a biological ligand and its chemical analyte.
Webinars will be available for unlimited on-demand viewing after live event.
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