DEC 04, 2020 9:00 AM PST

IOTest Myeloid Activation CD169-PE/HLA-DR-APC/CD64-PB Antibody Cocktail - Visualizing immune response during infections


Abstract

Date: December 4, 2020

Time: 9:00am PST, 12:00pm EST

Activation of Myeloid cells and interferon release is an early response to infection. The 3-marker combination (CD169/CD64/HLA-DR) gives an excellent overview of the innate immune response. The flow cytometry assay can effectively differentiate the immune response to bacteria or viruses.
Bacterial stimuli: CD64 overexpression on neutrophils (nCD64).
Viral stimuli: CD169 overexpression on monocytes (mCD169).
Recent stimulus: increased HLA-DR, Overstimulation/Immune exhaustion: decreased HLA-DR.
Further, the assay, using whole blood, is rapid and easy to perform, making this an invaluable tool in clinical research on antibiotic resistance, and studying interferon signaling during infections.


 
Learning Objectives:

  • Describe Myeloid cell activation and how it is specific for viral and bacterial infections due to differential interferon signaling.
  • Explain how Markers CD64 and CD169 can be effectively used to differentiate between the types of infections.

 

 

* For Research Use Only. Not for use in diagnostic procedures.

 

 

Webinars will be available for unlimited on-demand viewing after live event.

 

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
FEB 24, 2021 10:00 AM PST
C.E. CREDITS
FEB 24, 2021 10:00 AM PST
DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
MAR 18, 2021 8:00 AM PDT
C.E. CREDITS
MAR 18, 2021 8:00 AM PDT
DATE: March 18, 2021 TIME: 8:00am PDT Sequencing of bulk cells, single cells, and nuclei is opening doors in the understanding of complex biological processes....
APR 19, 2021 8:00 AM PDT
C.E. CREDITS
APR 19, 2021 8:00 AM PDT
Date: Apri 19, 2021 Time: 8:00am PDT, 5:00pm CEST Since the inception of modern biological research, BioSafety has evolved into a critical consideration in Good Laboratory Practices (GLP). Wi...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
Loading Comments...
Show Resources