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SEP 17, 2020 11:00 AM PDT

Lung-Chip - Accelerating Study of Viral Infection and Therapeutics

Sponsored by: Emulate Bio
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • EVP European Scientific Liaison Emulate, Inc.
    Biography

      Lorna Ewart is Emulate’s Executive Vice President in Europe.  She brings over 20 years’ experience in the pharmaceutical industry, spanning Bioscience and Drug Safety.  In her role at Emulate, Ewart is a member of the Executive Leadership Team and provides oversight for the corporate vision, goals and, science with academics, industry, and regulatory partners. Prior to joining Emulate, Ewart created Veroli Consulting Limited. Here, she served as an independent scientific consultant directing academics, start-up biotechnology companies, and pharmaceutical companies working with Organ-Chips and organoids.  Within the pharmaceutical industry, Ewart rapidly developed a reputation as a valued partner with academic institutions, regulatory bodies, and technology developers and most recently successfully established the Microphysiological Systems Centre of Excellence within AstraZeneca’s R&D Biopharmaceuticals Unit in Cambridge, UK.  This positioned AstraZeneca at the leading edge of industrial adoption of Organs-on-Chips technology. Earlier in her career, Ewart was the therapy area lead toxicologist for Respiratory and Inflammation in AstraZeneca’s Gothenburg R&D site, Sweden.  Following her Ph.D., she joined the Respiratory and Inflammation research area within AstraZeneca, optimizing efficacy in small molecules before moving into preclinical Drug Safety where she led a Safety Pharmacology team delivering GLP data across multiple therapeutic areas. Ewart is a classically trained pharmacologist and obtained her honors degree at the University of Aberdeen and her Ph.D. at the William Harvey Research Institute in London.  She has authored over 35 publications and is a fellow of the Royal Society of Biology and British Pharmacological Society.


    Abstract

    Infectious diseases, such as COVID-19, are challenging to study in animal models due to species differences, and conventional 2D cell-based systems lack the complexity to appropriately model the disease or immune response in humans. Organs-on-Chips offer a human relevant system that can recreate key disease phenotypes in a more physiological microenvironment due to their complex 3D architecture and mechanical forces induced by flow and stretch. In this webinar, we discuss how the Airway Lung-Chip and Alveolus Lung-Chip can be used to study viral infection and accelerate the development of new therapeutics.

    Learning Objectives:

    1. Learn how Organs-on-Chips technology can be applied to recreate key aspects of pulmonary physiology, specifically the creation of Airway and Alveolus Lung-Chip models

    2. Review data demonstrating how the Airway Lung-Chip can be used to study viral infection and evaluate the efficacy of therapeutic interventions


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