Webinars

APR 26, 2022 7:00 AM PDT

Modelling of cellular interactions in mixed murine organoids

Sponsored by: Andor

C.E. Credits: P.A.C.E. CE ｜ Florida CE

Speaker

Event Date & Time

Date: April 26, 2022

Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CET)

Abstract

Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We developed a model of mixed murine organoids and enteroid monolayers to study such complex cellular interactions in a mammalian system. We combined this model with (time-lapse) microscopy and transcriptome analysis to show that cell competition drives growth of cancer cells by active out-competition of wild-type cells through forced cell death and cell-state change in a JNK-dependent manner.

Learning Objectives

Identify generation of mixed murine organoids and enteroid monolayers
Discuss the use of (time-lapse) microscopy to follow cellular behavior
Discover insight in the role of cell competition in tumor growth

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Modelling of cellular interactions in mixed murine organoids

Saskia J.E Suijkerbuijk