A Modern Approach to Screening for Monoclonal Gammopathies using Digital Workflows

Monoclonal gammopathies (MGs) comprise a broad set of diseases involving the abnormal clonal proliferation of plasma cells. Treatments for MGs range for watchful monitoring to multidrug chemotherapeutic regimens and bone marrow transplant. The clinical laboratory plays a central role in guiding these therapeutic decisions by performing a number of assays that detect monoclonal proteins within the patient's blood or urine. These assays are typically performed as a panel or as part of a reflexive algorithm to improve the accuracy and information yield. However, the complexity of these algorithms requires careful coordination between the medical technologists and the reviewing pathologist. This presentation will cover our institutional experience developing and adopting a computer-based workflow for coordinating and interpreting MG screening panels within the Phoresis (Sebia) computer application.

 

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