MSI Predicts Immunotherapeutic Response

Dr. Eshleman will be discussing how MSI provides a functional readout of mismatch repair status, the implications of mismatch repair deficiency in cancer cells, and how elevated mutation rate associated with MSI-H tumor cells drive the production of neoantigens thought to contribute to immunotherapeutic response.
 

Learning Objectives: 

•    Recall implications of mismatch repair deficiency in solid tumors 
•    Define Key advantages of Long Mononucleotide Repeats (LMRs) in detecting microsatellite instability