Multi-colour electron microscopy (MCEM) combines ultrastructural electron data with elemental information, transforming traditionally grey scale electron micrographs into colourful images that combine structure and composition. Energy dispersive x-ray spectrometry (EDS) is a rapid and relatively easy method for determining elemental distribution by measuring the energy of characteristic x-rays emitted from a sample when exposed to an electron beam. Recent key developments in EDS technology have increased the potential for accurate analysis of light elements in biological samples. This tech talk will discuss how our Ultim Extreme EDS detector is optimised for life science applications, ranging from the identification and mapping of endogenous, native elements to the characterisation of implant materials, pollution particles and the interaction of cells and tissues with biomaterials.