APR 13, 2021 3:00 PM BST

A physiologically-relevant 3D ECM for in vitro oncology research and intelligent high-content imaging of 3D models

Sponsored by: Molecular Devices
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Elodie Vandenhaute, Study Director, HCS Pharma
    Biography

      Elodie Vandenhaute, PhD in neurobiology, has been working as a study director in HCS Pharma company since 2017. She received her PhD in 2011 in the laboratory of Pr Romeo Cecchelli (Artois University, France), for her work on the development and characterization of in vitro blood-brain barrier models for fundamental research, and their applications in drug discovery. With different post-doctoral positions in Germany and France, she has acquired wide experience of in vitro modelling for the study of brain cell responses in health and disease (brain metastasis, cerebral amyloid angiopathy, Alzheimer's disease, hypoxia).

    • Guillaume Frugier, Senior Imaging Applications Scientist, Molecular Devices
      Biography

        Guillaume Frugier, PhD in neuroscience and pharmacology. Guillaume has been working with Molecular Devices for 10 years, specializing in high-content cell imaging and analysis.


      Abstract

      Date:  April 13, 2021

      Time: 3:00pm BST, 4:00pm CEST

       

      Trends continue towards the development of more sophisticated and physiologically relevant 3D in vitro models, such as stem cell-derived models, organoids, organ-on-a-chip, and cells in extracellular matrices. In parallel, fully automated imaging solutions now enable an ever-deeper insight into cell compartments while intelligent software tools are turning the high information content of microscopy images into meaningful results.

      In this webinar, HCS Pharma scientists will present a patented 3D cell culture system, BIOMIMESYS®, which mimics the key features of the cellular microenvironment, either physiological or pathological, in a ready-to-use format. This unique 3D extracellular matrix (ECM) is different from standard hydrogels used for 3D cell culture as it is made of native ECM components: Hyaluronic Acid (HA) combined with collagens, adhesion peptides, in the form of a unique hydroscaffold which exhibits dual behavior between hydrogels and solid scaffolds. Solid tumors are often associated with a modified microenvironment, with an enhanced collagen content and increased stiffness. These ECM changes are now recognized as important drivers of cancer initiation and progression, and also impact the treatment of cancer lesions. The BIOMIMESYS® Oncology matrix allows cancer cells to be cultured in a tumor-like environment, with the possibility to tune the composition and stiffness of the matrix. We will show how this 3D model can be used in cancer research through results obtained by confocal imaging and subsequent image analysis.

      We will also present our next generation of automated imaging system, the ImageXpress Confocal HT.ai, which brings best in class hardware flexibility and throughput as well as machine learning capabilities to translate complex 2D or 3D images into scientific discovery.

       

      In this webinar, you will learn:

      • Utilizing a relevant 3D cell culture platform for oncology research
      • Optimizing the setup of a high-content screening platform for 3D in vitro models
      • Improving sensitivity, speed, and assay quality for 3D and complex biological assays using a high-content imaging laser-based system

       

       

       

       

      Webinars will be available for unlimited on-demand viewing after live event.

       

      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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