APR 08, 2021 11:00 AM PDT

Pneumonia Diagnosis: Bacterial Superinfection in COVID-19 Patients

Sponsored by: OpGen, Inc.
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Professor/Head of Division of Clinical Microbiology and Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Biography
      Professor Christian G. Giske (MD, PhD) is the chief physician of bacteriology, mycobacteriology and mycology at Karolinska University Hospital, Solna, Sweden. He is also Head of the Division of Clinical microbiology and the Division of Clinical immunology at the Department of Laboratory Medicine at Karolinska Institute, where he also leads a research group. The most important research activities in Prof. Giske's research group pertain to deep-characterization of molecular mechanisms of resistance, virulence, and molecular epidemiology of extensively drug-resistant enteric bacilli. Prof. Giske's research is strongly translational, involving extensive collaboration with infectious diseases (including mycobacteriology), hematology, and intensive care. Prof. Giske also has extensive international collaboration, serving in the advisory board of ECDC's European resistance surveillance, and as the chair of the European Committee on Antimicrobial Susceptibility Testing. Activities in Prof. Giske's research group include studies of management of bloodstream infections and respiratory infections, molecular diagnostics based on next-generation sequencing, susceptibility testing of Mycobacterium tuberculosis, studies of intestinal carriage of resistant bacteria, pharmacodynamics studies of combinations of antimicrobials, clinical application of bacteriophages as antimicrobials, and next-generation sequencing as a tool for deep-characterization and susceptibility testing of bacteria.
    • Medical and Public Health Microbiology Fellow, Indiana University School of Medicine, Department of Pathology and Laboratory Medicine, Indianapolis, IN
      Biography
        Drew Bell, PhD is currently a Medical and Public Health Microbiology Fellow at Indiana University School of Medicine. He completed his PhD in Pathobiology at Johns Hopkins School of Medicine studying peptidoglycan metabolism in P. aeruginosa. During fellowship he has focused on developing antimicrobial susceptibility testing, nucleic acid amplification testing, and other molecular diagnostic methods for use in the clinical microbiology lab.

      Abstract
      Date:  April 8, 2021
      Time: 11:00am (PDT),  2:00pm (EDT),  8:00pm (CEST)
       
      Pneumonia is a deadly condition with clinical outcomes highly dependent on prompt and appropriate therapy. Diagnosis of pneumonia is challenging, co-infections pose further complexity in the best of circumstances, and diagnosing bacterial superinfections during COVID-19 has been difficult, particularly in critically ill hospitalized patients. Bacterial documentation is essential to assess co-infection in COVID-19 critically ill. Clinical presentation, inflammatory markers, and bilateral radiological infiltrates can be misleading and not optimally suitable for the diagnosis of a bacterial superinfection. Consequently, empirical antibiotic therapy is initiated until microbiological assessment of pathogens is confirmed. Molecular diagnostic (MDx) platforms are addressing the challenges of pneumonia diagnosis, paving the way for shorter hospital stays through rapid and sensitive pathogen identification. The use of MDx tools and the initiation of narrow-spectrum antibiotics are key elements of antimicrobial stewardship guidelines, especially in severe COVID-19 patients. There are now several platforms available for identifying the significant causes of bacterial pneumonia and relevant antibiotic resistances. In this presentation we will be presenting the results of the Unyvero Panel for Lower Respiratory Tract (LRT) infections and Hospitalized Pneumonia (HPN) compared to standard of care practices (microbiological culture) for detection of bacterial pathogens from lower respiratory tract specimens obtained from critically ill hospitalized patients including those with COVID-19. Included are also several cases of Pneumocystis jirovecii pneumonia (PJP), as MDx techniques provide a notable alternative to the insensitive morphological methods of PJP diagnosis. We will consider retrospective chart review of patient demographic data, treatment course, and clinical outcomes that demonstrate the potential clinical impact of implementing the Unyvero Lower Respiratory Tract Panel.
       
      Learning Objectives
      • Illustrate the performance of molecular techniques compared to culture for lower respiratory tract specimens.
      • Demonstrate the potential effects of molecular diagnostics on the clinical course of these patients.
      • Discuss the strategies for implementing molecular tools into a respiratory diagnostic algorithm.
       
       
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