OCT 28, 2014 7:00 AM PDT

Quality-by-Design Development of a Purity Method Using ACQUITY UPLC H-Class and QDa Mass Detector

Speaker

Abstract

Pre-recorded webinar available for immediate playback.

Traditional method development, in which an LC method is developed principally by trial-and-error, is time consuming and may not result in a robust method. In addition, taking this approach provides no understanding of the influence of key factors on the results. Conversely, modern systematic method development strategies using statistical or modeling software tools to generate experimental designs and explore method robustness offer numerous advantages and can provide a fast and efficient approach for method development.

Chromicent GmbH (Berlin, Germany) managing directors Alexander Schmidt and Mijo Stanic are experts in the development and validation of analytical methods according to the latest quality-by-design approaches. The aim of their recent work has been to apply quality-by-design principles to build in a more scientific and risk-based, multifactorial strategy in the development of a new UHPLC methods. In this webinar, they will describe the application of their approach in the development of a new purity method for a well known API. The final method, with an analysis time of only 4 minutes, provides a 40-fold increase in productivity compared to the existing method published in the European Pharmacopeia.


Show Resources
You May Also Like
MAR 09, 2022 9:00 AM PST
C.E. CREDITS
MAR 09, 2022 9:00 AM PST
Date: March 9, 2022 Time: 9:00am (PST), 12:00pm (EST) For laboratories that operate within a quality management system, purchasing the correct freezer is business critical. While some may th...
MAR 16, 2022 8:00 AM PDT
C.E. CREDITS
MAR 16, 2022 8:00 AM PDT
Date: March 16, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Handling of potent and/or hazardous substances is commonplace in sev.....
DEC 09, 2021 6:00 AM PST
C.E. CREDITS
DEC 09, 2021 6:00 AM PST
Date: December 9, 2021 Time: 6:00am (PDT), 9:00 am (EDT) As the number of biotherapeutic candidates in development is increasing, the requirements of analytical tools to understand the molec...
MAR 16, 2022 9:00 AM PDT
C.E. CREDITS
MAR 16, 2022 9:00 AM PDT
Date: March 16, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEDT) With a renewed and growing interest in therapeutic oligonucleotides (oligos) across the pharmaceutical industry, the req...
NOV 30, 2021 10:00 AM PST
C.E. CREDITS
NOV 30, 2021 10:00 AM PST
Date: November 30, 2021 Time: 10:00am (PDT), 1:00pm (EDT) The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to...
MAR 23, 2022 11:00 AM PDT
MAR 23, 2022 11:00 AM PDT
Date: March 23, 2021 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEDT) In this presentation, Dr. Middleton will review the development and deployment of large-scale saliva-based COVID-19 test...
Loading Comments...
Show Resources