Reactive Extrusion and Temperature-Controlled Ball Milling: Scaling-up Solvent-Free Organic Synthesis from Milligram R&D Work

Small-scale solvent-free organic synthesis--aka, "Mechanochemistry"--is rapidly growing in popularity.  In part, this growth is due to the ability to perform reactions in a cheaper, faster, safer, and more environmentally friendly manner. This presentation will explore the scale-up process starting from milligram-scale R&D.