Assistant Professor, Cincinnati Children's Hospital Medical Center
BIOGRAPHY
APR 15, 2020 9:00 AM PDT
Single-cell multi-omics: DNA methylation and 3D genome
Sponsored by: Zymo Research
Speaker
Event Date & Time
DATE: April 15, 2020
TIME: 9:00am PT, 12:00pm ET
Abstract
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
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