APR 21, 2021 5:00 PM CEST

Immunology Researchers share their Spatial Discoveries in SARS-CoV-2 host response and in multiple sclerosis

Speakers
  • British Society for Immunology Chief Executive
    Biography
      Doug is currently Chief Policy and Research Officer at the Alzheimer's Society, the UK charity that funds research into dementia and supports people with this condition and their families. He has led a number of high profile initiatives across research and policy including the establishment of the new £300m UK Dementia Research Institute.
      Doug comes from an immunology background, having completed a PhD at the University of Cambridge in HIV research, followed up by a postdoctoral position with Jean Langhorn at NIMR, Mill Hill (now the Francis Crick Institute) working on malaria and stem cells and publishing in top journals. He subsequently worked for the MS Society leading their biomedical research programme. He is currently a Trustee of the Association of Medical Research Charities (AMRC), the national umbrella organisation for medical research charities.

    • Group Leader and Head of Core Facility Mouse PathologyUniversity Medical Center Hamburg Eppendorf UKE
      Biography
        Susanne has an important academic background, having carried out her research in various academic centre throughout the world. Susanne worked at Harvard Med School on Microglia disfunction and prion clearance after having focused on the trafficking of prion proteins and the Universty Medical Hamburg-Eppendorf. Prior to these engagements, Susanne had worked in the virology and immunology research field in Gottingen. Today Dr Krasemann is the group leader and Head of Core Facility Mouse Pathology University Medical Center Hamburg Eppendorf UKE Institute of Neuropathology.
      • Researcher at Queen's University Belfast
        Biography
          Michelle received a masters in neuropharmacology and assisted research on modulation of the glial scar before pursuing a PhD on the activation of endoplasmic reticulum stress signalling in myelination at the National University of Ireland Galway. Her current project, as Research Fellow at Queen's University Fellow, involves studying the regenerative profile of immune cells in multiple sclerosis.

        Abstract
        Date:  April 21, 2021
        Time: 8:00am (PDT),  11:00am (EDT),  5:00pm (CEST)
         
         
        Spatial Answers in Immunology - Doug Brown
        Doug will be the chair of this session and will introduce the winners of the 2020 British Society for Immunology, NanoString and Illumina Spatial Biology Grant. Doug will also moderate a short panel discussion on the use of Spatial Biology for Immunology research.
         
        Blood Brain Barrier Dysregulation in COVID-19 - Susanne Krasemann
        The corona virus SARS-CoV 2 has led to a worldwide pandemic.Infected people may develop neurologic dysfunctions with sometimes functional impairment of the respiratory center in the brainstem.
        We investigated in patients deceased from COVID-19 whether direct neuro-invasion of the brainstem by SARS-CoV 2 led to the proposed dysfunction. Our preliminary data point to a putative SARS-CoV 2 dependent dysfunction of the endothelial cells of the blood-brain-barrier (BBB), leading to loss of proper function and potential access of immune cells to the brain. We investigated expression profiles of selected brain endothelial cells with and without adjacent immune infiltrations in the brain of people deceased from COVID-19 to help define molecular mechanisms and identify key proteins involved in the execution of brain vessel dysfunction in severe and fatal COVID-19 cases.
         
        Tertiary Lymphoid Structures in MS - Michelle Naughton
        Multiple Sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) that strikes young adults in the prime of their lives.
        A hallmark of the progressive phase of MS is the accumulating neurodegeneration and cortical demyelinating pathology. Extensive immune infiltrates can exist as simple lymphoid aggregates or more organised assemblages termed tertiary lymphoid structures (TLS). The relative grade of meningeal lymphoid aggregates correlates with the severity of clinical disease (Bevan et al., 2018).
        The study investigates the characterization of the immune cell composition of TLS in MS and the cellular alterations they incur in the cortex by carrying out the GeoMx Whole Transcriptome Atlas analysis of TLS and their effects on underlying neurons in rare post-mortem MS samples
         
        Learning Objectives
        • Learn about gene expression changes in situ, induced by Covid-19, in the central nervous system
        • Learn about Spatial Biology with NGS read out in Immunology Research
        • Discover the GeoMx and NextSeqTM 2000 sequencing system workflow
         
        For Research Use Only. Not for use in diagnostic procedures
        • April 21: Immunology Researchers share their Spatial Discoveries in SARS-CoV-2 induced changes in the CNS and their in situ analysis of the immune cell composition of TLS in MS.
          • Topics
            • Spatial Answers in Immunology
            • Blood Brain Barrier Dysregulation in COVID-19
            • Tertiary Lymphoid Structures in MS

         

        Webinars will be available for unlimited on-demand viewing after live event.
         

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