APR 22, 2021 5:00 PM CEST

Researchers share their Spatial Discoveries in Neurology Research

Speakers
  • Professor, Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, Moscow, Russia
    Biography
      Philipp Khaitovich completed undergraduate studies in molecular biology at Moscow State University in 1995 and PhD in biochemistry at the University of Illinois at Chicago in 1999. From 2000 till 2006 Philipp worked as a postdoctoral researcher at the Max Planck Institute for Evolutionary Anthropology at the department of Evolutionary Genetics headed by Prof. Svante Pääbo.In September 2006, Philipp took a faculty position at the Institute for Compu-tational Biology jointly established by the Chinese Academy of Sciences and the Max Planck Society in Shanghai China. In 2012 Philipp was promoted to an institute director posi-tion.From 2012, Philipp is a fellow member of Max Planck Society of Germany, as well as ad-junct Professor at ShanghaiTech University in Shanghai, China.Philipp joined Skoltech as a Full Professor in April 2014
    • Senior Research Fellow , UCL Queen Square Institute of Neurology, London
      Biography
        Joan Liu is a Senior Lecturer in Cellular Pathology at School of Life Sciences, University of Westminster, and a Honorary Senior Research Fellow at Division of Neuropathology, UCL Queen Square Institute of Neurology. Her research investigates the pathomechanisms underlying structural pathologies, inflammation and neurodegeneration in human Epilepsy

      Abstract
      Date:  April 22, 2021
      Time: 8:00am (PDT),  11:00am (EDT),  5:00pm (CEST)
       
       
      System transcriptomics of the schizophrenia brain - Phillip Khaitovich
      Schizophrenia tops the psychiatric disorder list, both historically and clinically. Despite decades of research and dozens of hypotheses, we still do not understand its mechanisms. While the contemporary research focuses on the prefrontal cortex, our transcriptome assessment of 35 brain regions identified part of the temporal lobe and subcortical regions, including white matter tracks, as primary schizophrenia targets. Spatial transcriptome and proteome analyses of the prefrontal and temporal cortices confirmed this result, further revealing particular alterations of the superficial cortical layers involving genes linked to schizophrenia by the whole-genome association studies.
       
      Single-cell gene expression studies in human Focal Cortical Dysplasia - Joan YW Liu
      Focal Cortical Dysplasia (FCD) is the commonest malformation encountered in surgically-resected brain tissue of patients with Focal Epilepsy, and it is characterised by dyslamination and the presence of abnormal cell types, including dysmorphic neurons and balloon cells. It remains unclear how these abnormal cell types contribute to epileptogenesis. The work presented today shows results obtained using the GeoMx Digital Spatial cell Profiler technology to analyse the transcriptome of dysmorphic neurons and balloon cells in the surgically-resected brain samples of four patients with Focal Cortical Dysplasia Type IIB.
       
      Learning Objectives:
      • Discover Spatial Genomics in Neuro Research
      • Learn from your peers about Neurology Spatial Discovery
      • Find out about the advancements in schizophrenia and epilepsy 
       
      • April 22: Researchers share their Spatial Discoveries in Neurology Research
        • Topics
          • System transcriptomics of the schizophrenia brain - Philipp Khaitovich
          • Single-cell gene expression studies in human Focal Cortical Dysplasia - Joan Liu
       
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