Heptares Therapeutics is a structure based drug discovery and development company which uses it StaR technology to enable X-ray structures, fragment screening and other biophysical techniques for G-protein coupled receptors. These methods have been applied to previously undruggable or challenging GPCRs resulting in a pipeline of new candidate medicines for diseases including Alzheimer's disease, schizophrenia and ADHD. This talk will give examples of how structure based methods have been applied across the superfamily of GPCRs.