MAY 08, 2020 10:00 AM PDT

TCR-seq & BCR-seq Solutions: Applications to Clinical Research Projects

Speaker
  • Associate Professor and Scientific Director of Genomics at National Jewish Health (NJH)
    Biography
      Brian P. O'Connor, PhD, is an Associate Professor and Scientific Director of Genomics at National Jewish Health in the Center for Genes, Environment, and Health. His work focuses on understanding how epigenetic mechanisms regulate the decision processes governing immune cell activity in the context of disease. The immune system is comprised of multiple types of autonomous cells that must work together to influence the outcome of disease. The identity and function of the autonomous immune cells are influenced by microenvironmental stimuli, which in turn affect the epigenome. Currently, Dr. O'Connor's lab examines the cross talk between environmental stimuli (such as diet or inflammation), the immune system, and disease (such as Asthma).

      Dr. O'Connor received his Ph.D. in immunology and has been trained in organismal, cellular and molecular immunology. His post-doctoral training was in immune epigenetics and molecular biology.

    Abstract
    DATE:  May 8, 2020
    TIME:  10:00am PT, 11:00am MT, 1:00pm ET
     
     
    The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex datasets can be mined to examine immune regulation and/or identify potential biomarkers has evolved considerably over the years. With advances in sequencing technologies and development of comprehensive, intuitive analysis tools, NGS-based repertoire analysis has become more accessible to the broader research community. Thermo Fisher Scientific’s streamlined and user-friendly TCR- and BCR-seq laboratory and analysis pipelines enable just about anyone to incorporate this powerful tool into their research program.
     
    In this discussion, we will present examples of how repertoire analysis can be used to answer different types of research questions. Highlight summaries of different studies leveraging TCR and BCR sequencing in human disease research to better understand mechanisms involved in inflammatory diseases will be presented. Methods of experimental design, sequencing, and analysis will be introduced for each, with examples of figures that can be generated with the user-friendly analysis portal.
     
    Learning objectives:
    • The importance of biomarker development and discovery in inflammatory diseases, including those caused by infectious agents like SARS-CoV-2
    • Molecular applications in immune repertoire sequencing and immune response
    • Basic methods of analysis
     
     
    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

     


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