MAR 20, 2014 12:00 PM PDT

The Genetics of Alzheimer's disease

Presented at: Neuroscience
Speaker
  • Samuel & Mae S. Ludwig Professor of Genetics in Psychiatry, Professor of Neurology, Dept. of Psychiatry, Washington University School of Medicine
    BIOGRAPHY

Abstract

Alzheimers disease (AD) is a common neurodegenerative disorder characterized clinically by progress decline in memory and thinking and pathologically by the presence of senile plaques and neurofibrillary tangles. The strongest risk factors for AD are age family history. Early genetic studies of AD focused on families where the disease exhibited an autosomal dominant pattern of inheritance. Genetic studies in these families identified mutations in three genes that generally cause an early onset form of the disease. These genes pointed to the amyloid peptide, which is the primary component of the senile plaques as central to disease pathogenesis. Subsequent studies in the late onset form of the disease using genome-wide approaches to study both common and rare genetic variation have identified evidence for many more genes that can influence risk for AD. These studies have uncovered other pathways including innate immunity and lipid metabolism that also play key roles in disease risk and point to potential therapeutic targets for treatment of disease.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
AUG 24, 2021 11:00 AM PDT
C.E. CREDITS
AUG 24, 2021 11:00 AM PDT
Date: August 24, 2021 Time: 11:00am (PDT), 1:00pm (EDT) Electron-based dissociation mechanisms have shown great promise for advanced characterization of biomolecules. However, routine adopti...
MAR 20, 2014 12:00 PM PDT

The Genetics of Alzheimer's disease

Presented at: Neuroscience

Specialty

Clinical Research

Research

Biology

Microbiology

Genetics

Dna

Health

Research And Development

Molecular Biology

Infectious Disease

Gene Expression

Earth Science

University

Molecular Diagnostics

Medicine

Geography

Asia50%

North America25%

Registration Source

Website Visitors100%

Job Title

Medical Laboratory Technician100%

Organization

Hospital25%

Academic Institution25%

Manufacturer - Other25%


Show Resources
Loading Comments...
Show Resources