Understanding how in vitro macrophage assays drive IO drug development forward

DATE:  October 20th, 2020

TIME:   09:00am PDT, 12:00pm EDT

Tumor-associated macrophages (TAMs) are key cells in the tumor microenvironment (TME) with diverse immune functions that have a major influence on tumorigenesis. Thus, TAMs have gained increasing attention as promising targets for the development of effective anti-cancer immunotherapy. In pre-clinical drug discovery research, in vitro macrophage assays are commonly performed to monitor the effect of immunotherapeutic candidates. These assays represent a helpful tool in predicting the effect of immunotherapeutics on TAMs in vivo.
 
Learning Objectives:

• Understand the benefits of using human-derived myeloid cells for in vitro assays in pre-clinical drug discovery research
• Learn about the importance of in vitro macrophage polarization assays to help evaluate pro- and anti-inflammatory phenotypes
• Get insights on the use of in vitro myeloid suppressive assays for the functional evaluation of candidates
• Understand the role of phagocytosis and ADCP assays for candidate monitoring

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LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.