Using non-hypothesized based approaches for biomarker development

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Sponsored by: SomaLogic
Speaker

Abstract
Date:  October 26, 2022
Time: 9:00am (PST),  12:00pm (EST), 6:00pm (CEST)
 
Current protein biomarkers are only moderately predictive in identifying individuals with mild traumatic brain injury or concussion. Therefore, more accurate diagnostic markers are needed for sport-related concussion (SRC). A case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium. The blood was collected within 48 hours of injury. Athletes with concussion were divided into 6 hours post-injury (0-6 hours post-injury) and after 6 hours post-injury (7 to 48 hours post-injury) groups. We applied a highly multiplexed proteomic technique that used DNA aptamers assay to target 1,305 proteins in plasma samples from athletes with and without a SRC. We identified 338 plasma proteins significantly differed in abundance in concussed athletes compared to non-concussed athletes. The top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve (AUC) of 0.954 (95% confidence interval 0.922 to 0.986). Specifically, after 6 hours of injury, the individual AUC of plasma erythrocyte membrane protein band 4.1 (EPB41) was 0.956 and 0.875 for alpha synuclein (SNCA).
 
Learning Objectives
  • Understand current limits of protein quantification
  • Describe ways to improve biomarker identification and measurement related to brain injuries
  • Determine ways to address current limitations to personalize medicine approaches for brain injuries.
 
 
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