Applications of targeted NGS panels for clinical research of primary immunodeficiency diseases

Primary immunodeficiencies (PIDs) are a group of more than 250 genetic disorders that disrupt the immune system, resulting in susceptibility to life-threatening infections, autoimmune disease, or malignancy. 

Identifying the genetic causes of PIDs is essential for understanding the molecular pathways leading to these diseases, but is challenging because of phenotypic heterogeneity, pleiotropy, and the accessibility of genetic testing.

The advent of next-generation sequencing (NGS) has been instrumental in accelerating the pace of discovery in the field of PID research and testing. NGS enables high-throughput screening of many genes in a rapid, cost-effective manner and thus has the potential to transform the strategies and workflow of research on PIDs. 

In this webinar, our expert speakers will discuss how they implemented a next-generation sequencing approach to PID research in a translational research lab. They will present their hands-on experience in utilizing a targeted NGS panel, compare it to conventional approaches for studying PIDs, and demonstrate the applications of this technology to translational research in PIDs.

For Research Use Only. Not for use in diagnostic procedures.