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Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
Solute carriers include numerous uptake transporters that serve as major regulators of drug absorption, disposition, and clearance. Indeed, drug interactions or genetic variation that alter...
The 21st Century Cures Act, along with the FDA's Real-World Evidence (RWE) framework, has established a foundation for incorporating real-world data (RWD) into regulatory decision-making...
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...
There are known health outcome disparities among those with pancreatic neuroendocrine tumors (pNET) of minority race and those living with adverse social determinants of health (SDOH) (rural...
Immunotherapy has changed the landscape of oncology, improving survival rates for many patients across a variety of malignancies. Two antibody-based immunotherapies, immune checkpoint inhibi...
To determine efficacy of specific complementary therapies to advance evidence-based, integrative healthcare, the complementary modality should first be introduced to stakeholders to determin...
Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkp...
Genomic research has long been skewed toward European populations, leading to significant underrepresentation of Non-European groups in both research studies and genomic databases. This bias...
Fluorescence microscopy offers robust, multi-parametric and scalable analysis of cell level activity in heterogenous populations with spatial and temporal resolution, often critical for effe...
The cellular physiology of microbes can vary significantly within a population, even when exposed to identical external conditions. Recent theoretical and experimental studies have shown tha...
Heart failure, in the simplest of terms, indicates that a problem with the ventricles is preventing the heart from filling and/or pumping correctly. It is the result of a complex mechanical...
abstract Learning Objectives Understand how the health disparity affects ordering M-protein testing at the right time. Discuss Analytical considerations of the test panel/methods ordered Ide...
A unique opportunity to deepen understanding of how labs can contribute to antibiotic stewardship efforts by running efficient Procalcitonin testing, yielding significant impacts on patient...
The field of carrier screening has rapidly developed over the past several years, in terms of technology, guidelines for testing, and patient knowledge. This webinar aims to educate the audi...
1) Microscope slides and coverglass are used in many parts of the lab while knowledge of how these items are made and the technical properties they have is limited. 2) By not understanding t...
Blood Cultures are the gold standard test for Sepsis diagnosis and an essential first step in infectious organism identification. Improving its quality is critical to the outcomes for a pati...
Join Dr. Steben and Dr. Riedel in their discussion of the HPV landscape and the shift to primary screening. Dr. Steben will set the scene with a discussion of: HPV prevention and prevalence...
Neural organoids derived from patient-specific iPSC lines can help open doors toward studying human brain development, physiology, and disease progression. The increased cell-cell interacti...
Spatial transcriptomics offers a revolutionary approach to understanding the tumor microenvironment (TME) in solid tumors by preserving the spatial context of gene expression, which is cruci...
Recently, the American Association of Clinical Chemistry (AACC), now Association of Diagnostics & Laboratory Medicine (ADLM), in collaboration with the American Diabetes Association (ADA...
Thyroid abnormalities affect a considerable portion of the population. Globally, there is a large population of people who have undiagnosed thyroid dysfunction or are at risk of developing i...
High-resolution spatial transcriptomics stands at the forefront of technological advancements, offering transformative capabilities in the domain of tumor biology research. In this presentat...
Cytomegalovirus (CMV) is a ubiquitous infection and congenital CMV (cCMV) infection is the most common non-genetic cause of hearing loss in infants and children. However, most pregnant women...
Fine needle aspiration (FNA) plays a vital role in the evaluation of patients with thyroid nodules, in terms of distinguishing benign, non-neoplastic thyroid nodules that may be conservative...
Histology laboratorians in the research world move fast, but those who perform cryosectioning know that these particular tissues require lighting speed and precision. Cryosectioning is the a...
Precise protein quantification is a crucial step in workflows involving protein extraction, isolation, and analysis. Accurate knowledge of the concentration of your protein sample is essenti...