mouse monoclonal IgG1; Slit1 Antibody (G-4) is an IgG1 κ mouse monoclonal Slit1 antibody (also designated MEGF4 antibody, SLIL1 antibody or Slit-1 antibody) that detects the Slit1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Slit1 Antibody (G-4) is available as both the non-conjugated anti-Slit1 antibody form, as well as multiple conjugated forms of anti-Slit1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural development by acting as high-affinity signaling ligands for the repulsive guidance receptor, Roundabout (Robo) (1,2). Within the developing central nervous system (CNS) of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting a conserved function among vertebrate homologs. Slit is expressed in the midline of the central nervous system in both vertebrates and invertebrates, where it functions as a regulatory factor of mesodermal cell movement during gastrulation. Slit2 is a short range inhibitory guidance cue for retinal ganglion cell (RGC) axons that may mediate spatial progression of RGCs.