JUL 06, 2022 2:10 PM PDT

Promising New Treatment Strategy for Psoriasis and Psoriatic Arthrtis

WRITTEN BY: Annie Lennon

Researchers have identified a new potential strategy for inhibiting inflammation in both psoriasis and psoriatic arthritis. The corresponding study was published in the Annals of the Rheumatic Diseases by researchers in Austria. 

Over 8 million people in the US have psoriasis. Around a third of people with the condition go on to develop psoriatic arthritis. Thought to be an autoimmune condition, its triggers include infections, stress, and cold. It typically appears as rashes or plaques on the skin; however, can sometimes affect the nails and joints too as in psoriatic arthritis. 

In the present study, researchers reported that inhibiting S100A9, a gene linked to psoriasis, can reduce psoriasis severity throughout the body- and not just the skin. 

Although these findings came from mouse models, they confirmed that the mechanism might work similarly in humans due to analyses of S100A9 expression in skin, serum, and synovial fluid samples from people with psoriasis and psoriatic arthritis. 

They found, for example, that patients with psoriatic arthritis had significantly higher blood levels of S100A9, alongside several immune and inflammatory cells than patients with psoriasis alone. They further noted that levels of S100A9 and calprotectin- an inflammatory protein- could be used to distinguish between healthy individuals, those with psoriasis, and those with psoriatic arthritis. 

"Our study is an important step towards the development of targeted therapeutic options in the form of drugs that act systemically rather than locally on the skin," said Erwin Wagner from the Department of Dermatology and Department of Laboratory Medicine at the Medical University of Vienna. 

"We now know that the inflammatory responses in psoriasis and psoriatic arthritis are enhanced when S100A9 is only inhibited in skin cells," she continued. Drugs inhibiting S100A9 via tablets or drips may thus be able to treat the condition systematically.

 

Sources: Science DailyAnnals of the Rheumatic Diseases

 

About the Author
University College London
Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
OCT 03, 2022
Clinical & Molecular DX
Could Blood Samples Detect the Risk of Peripheral Neuropathy in Type 2 Diabetes?
OCT 03, 2022
Could Blood Samples Detect the Risk of Peripheral Neuropathy in Type 2 Diabetes?
Type 2 diabetes is a disease that impacts the body’s ability to respond to insulin. Insulin is a hormone made by t ...
OCT 01, 2022
Drug Discovery & Development
Capsule-based Fecal Microbiota Transplant Treats Clostridiodes Difficile Infection
OCT 01, 2022
Capsule-based Fecal Microbiota Transplant Treats Clostridiodes Difficile Infection
Oral treatment with Fecal Microbiota Transplant (FMT) via capsules containing freeze-dried microbes has similar effects ...
OCT 14, 2022
Drug Discovery & Development
Experimental Gene Therapy Restores Night Vision in Blind Patients
OCT 14, 2022
Experimental Gene Therapy Restores Night Vision in Blind Patients
Adults with a hereditary form of childhood-onset blindness experienced dramatic improvements in night vision within days ...
OCT 26, 2022
Health & Medicine
Cannabis Cells Use Hacking Strategies to Make THC and CBD
OCT 26, 2022
Cannabis Cells Use Hacking Strategies to Make THC and CBD
Scientists have discovered the cannabis plant uses cell production "hacks" to make cannabinoids such as THC an ...
NOV 14, 2022
Immunology
A Probiotic 'Backpack' Could Treat Inflammatory Bowel Disease
NOV 14, 2022
A Probiotic 'Backpack' Could Treat Inflammatory Bowel Disease
There are many types of microorganisms in the human gastrointestinal tract, and many of them perform important functions ...
NOV 15, 2022
Genetics & Genomics
Revealing the Mutations that Make Melanoma Immortal
NOV 15, 2022
Revealing the Mutations that Make Melanoma Immortal
Telomeres cap the ends of chromosomes, preventing breakage. Some cancer cells can use those protective caps to their adv ...
Loading Comments...