DATE: April 30, 2018
TIME: 8:00AM PT,  11:00AM ET

Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical  analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional structural  information not available from mass spectrometry, and reduce or eliminate the need for  chromatographic separation. These features offer significant improvements for quantitative targeted  metabolomics and clinical research analysis, as well as for untargeted (global) metabolomics studies.

This presentation will explore innovations in ion mobility/mass spectrometry for metabolomics,  lipidomics, and clinical research analysis. Techniques to be covered include both classic drift tube ion mobility  (IMS) and high‐field asymmetric‐waveform ion mobility (FAIMS), in conjunction with HRMS, MS/MS, and  LC/MS. Characterization and optimization of instrumental parameters critical for analytical performance will be explored, including ionization techniques, cationization and complexation of analytes for  improved mobility separation, and integration with chromatographic separation and MS/MS.  Applications will include a range of metabolomics, lipidomics, and targeted clinical research analyses. Specific examples will include rapid clinical research assays (vitamin D and its epimers), separation of isomeric  performance‐enhancing steroids, breath analysis research for potential early disease screening, and improvements in mass spec imaging. Recent advances in these areas will be highlighted, along with a perspective on the  metabolomics and clinical future of these approaches.

Learning Objectives:

• To understand how ion mobility is combined with mass spectrometry
• To understand how in mobility/mass spectrometry can be used for clinical research analysis and metabolomics

For Research Use Only. Not for use in diagnostic procedures.