Super immunodeficient mice such as the NOG-EXL and NSG-SGM3 combine severe immunodeficiency with transgenic expression of human myeloid-stimulatory cytokines. These mouse strains support an...
Single-cell sequencing (scSeq) is transforming disease research by revealing the intricate diversity across cell populations, uncovering crucial biomarkers and therapeutic targets often mask...
In 2022, there were approximately 1.4 million new cases of prostate cancer reported globally and over 397,000 deaths reported globally. PSA testing can have significant value in detecting me...
Capillary Electrophoresis is one of the newer methods for the detection and evaluation of hemoglobinopathies. It improves upon the alkaline gel electrophoresis platform with a similar migrat...
According to the CDC, in the United States, approximately 14.7% of adults have Diabetes, and another 10.8% have prediabetes. Unfortunately, as many as 8.7 million adults aged 18 years or old...
Predicting patient outcomes in cancer treatment is key to creating personalized and effective therapeutic plans. Join Dr. Osman in this engaging webinar as she delves into the cutting-edge w...
Urinalysis is a major diagnostic screening test in the clinical laboratory, with an important role in diagnosing and monitoring nephrological and urological conditions. Until recently, micro...
Labroots invites you to the 7th Annual Event in the CRISPR Virtual Event Series 2024 ! This event will continue the conversation of the abilities of CRISPR-based editing, next-gen editing to...
Identifying and verifying low frequencies of genomic alterations resulting from off-target editing, gRNA synthesis errors, cross-contamination, or other unintended gRNA activity is critical...
The increasing emergence of carbapenem-resistant organisms (CRO), including Enterobacterales (CRE), Pseudomonas aeruginosa (CRPA) and Acinetobacter baumannii (CRAB), is a major public health...
Directing nucleobase deamination or removal can generate precise genomic edits without double-stranded DNA breaks. However, a much broader spectrum of DNA chemical modifications is available...
Gene therapy has experienced an increasing number of successful human clinical trials, leading to 6 FDA approved products using delivery vectors based on adeno-associated viruses (AAV). Thes...
The three-part webinar series aims to provide a comprehensive understanding of the fundamentals and practical applications of Next Generation Sequencing (NGS) in the field of Molecular Patho...
Gene therapy involves introducing a functional gene into the patient's cells to replace a missing or defective one. It has revolutionized the field of medicine and has the potential to c...
T cell lymphocytes play a central role in the adaptive immune response. They are an essential tool of adoptive cell therapy for the treatment of chronic viral infections and malignant diseas...
Cell and gene therapy is at the forefront of medical innovation, offering transformative potential for treating complex diseases. However, achieving success in these therapies requires metic...
In today’s diagnostic test development landscape, the path to commercialization and generating topline revenue is marked by peaks and valleys. One of the first hurdles is navigating th...
Across the entire spectrum of the life sciences sector, from academia and hospitals to pharmaceutical and biotech companies, enormous amounts of resources are invested in the development of...
A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient transduction of airway epithelial cells to achieve therapeutic correction. Vehicles such as lysophosphati...
Inborn errors of metabolism (IEMs) are rare, devastating disorders caused by pathogenic variants in genes encoding key metabolic enzymes, with the liver playing a critical role in over 140 I...
Gene therapy is defined as the treatment of disease by transfer of genetic material into cells, to prevent, treat and potentially even cure a disease. Gene therapies can work by several mech...
The path from research discovery to effective immune cell therapies requires innovative approaches to match the challenges we face. Examining the full richness of biological complexity&mdash...
The development of cell and gene therapies faces immense pressure in terms of time and cost. Advanced therapy medicinal products (ATMPs) demand stringent quality control measures to ensure s...
Join us for an insightful webinar on the use of polygenic risk scores (PRS) for cardiovascular disease (CVD). The analysis of genetic variation across large populations plays a crucial role...
Labroots is excited to bring leading academia and industry experts, research scholars, healthcare and medical professionals, clinicians, oncologists, and top scientists under one virtual roo...
Learning Objectives 1. Discuss Neoantigen Mechanisms: Gain a comprehensive understanding of the mechanisms by which neoantigens are generated and recognized by the immune system, including t...
Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
The 21st Century Cures Act, along with the FDA's Real-World Evidence (RWE) framework, has established a foundation for incorporating real-world data (RWD) into regulatory decision-making...
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...